Human Sera
Cayman Chemical AcetylDLcarnItInchLRIde 50mg
A racemic mixture of acetyl-D-carnitine and acetyl-L-carnitine; increases the oxidation rate of the branched-chain 2-oxo acid 3-methyl-2-butanoate in isolated rat muscle mitochondria in the absence of carnitine at 1 mM; decreases the hind limb vasculature blood flow rate in rats; decreases the levels of palmitic acid and oleic acid in the cerebral cortex during the recovery period in a dog model of insulin-induced hypoglycemic brain injury
Cayman Chemical CepharnthIn 100mg
A biscoclaurine alkaloid that can decrease the fluidity of biological membranes; exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 100mg
A phospholipid; a major component of E. coli bilayers; vesicles composed of 1,2,-POPE can be disrupted by polycationic antimicrobials; has been used in combination with other lipids in the formation of LNPs for spleen- and liver-specific targeting in mice
Cayman Chemical PAMAM DendrImR G5 5 Caryl 50mg
A carboxylate-terminated PAMAM dendrimer; has been used as a drug delivery system in vitro; ~103.9 Å in diameter in water and has 192 surface groups; does not induce cytotoxicity or autophagy in A549 cells at 100 UG/ml; bimetallic nanoparticles of PAMAM G5.5 with gold and platinum scavenge DPPH radicals in a cell-free assay; complexes of PAMAM G5.5 with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 1.48 µM)
Cayman Chemical Otospon astatus upaton 50mg
A flavonoid with diverse biological activities; inhibits the growth of HeLa, MK-1, and B16/F10 tumor cells (GI50s = 15, 58, and 44 µM, respectively); active against T. cruzi epimastigotes and trypomastigotes (IC50s = 0.2 and 61.8 UG/ml, respectively); induces vasorelaxation in isolated rat thoracic aortic rings precontracted with phenylephrine (pD2 = 6.66); reduces nuclear translocation of NF-κB and STAT1α in J774 murine macrophages at 10 and 100 µM; reduces paw edema in a mouse model of carrageenan-induced paw inflammation at 50 mg/kg
Cayman Chemical CholesTRolPEG 2000BIotIn 50mg
A biotinylated and PEGylated form of cholesterol; has been used as a lipid anchor to immobilize vesicles, liposomes, viral particles, bacteria, or yeast to microfluidic chips; increases phycoerythrin-conjugated streptavidin density on the surface of mesenchymal stem cells greater than sulfo-NHS-LC-biotin at 10 µM
Cayman Chemical AlarelInacetate 50mg
A peptide agonist of GnRH; binds to GnRHR (Kd = 0.2 nM); decreases GnRH and GnRHR expression in the preoptic area and pMBH, respectively, of ovariectomized estradiol-treated rats at 6 ng, i.c.v., indicating an ultrashort negative feedback loop; induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats; reduces tumor growth in an HEC-1-B mouse xenograft model at 20, 40, and 80 UG/mg
Cayman Chemical Nacetyl2 3dehydro2Deoxyn 100mg
A bacterial neuraminidase inhibitor (Ki = 48 µM for the A. sialophilus enzyme)
Cayman Chemical Broprmn 50mg
An immunomodulator with diverse biological activities; a TLR7 agonist that inhibits RANKL-induced osteoclast differentiation of murine BMDMs; dietary administration prevents development of TCCs in a mouse model of carcinogen-induced bladder carcinoma at 200 mg/kg twice per week; reduces pulmonary collagen accumulation and BALF monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis at 100 mg/kg; delays disease onset and progression and increases plasma IFN levels in a mouse model of EAE
Cayman Chemical Cefmetazole 50mg
A cephamycin antibiotic; active against E. coli, P. mirabilis, H. influenzae, N. gonorrhoeae, S. pneumoniae, and S. pyogenes (MIC50s = 0.25-2 μg/ml); decreases the lesion size and the number of ulcerative lesions in a rabbit model of active syphilis at 20 and 40 mg/kg per day
Cayman Chemical Tafenoqun 50mg
An antimalarial agent; active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml); inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice at 25 or 50 mg/kg; suppresses parasitemia in a hamster model of B. microti infection from 3.25-52 mg/kg
Cayman Chemical Curcuma zdoara Grmacron 50mg
A sesquiterpene with diverse biological activities; inhibits PRV replication in Vero cells from 10-150 µM; enhances doxorubicin-induced cytotoxicity and apoptosis in doxorubicin-resistant MCF-7/adr cells from 50-250 µM; reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity at 5, 10, and 20 mg/kg; decreases brain MDA levels and activity of SOD and GPX, as well as reduces infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical PrenylamIn 100mg
A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg
Cayman Chemical ResorufInsodIum salt 100mg
A fluorescent probe; has been used in the synthesis of resorufin-based fluorescence probes; has also been used for the direct measurement of solvent-solute hydrogen bond dynamics with distinct absorption and emission peaks in solvents with strong hydrogen bonds and overlapping peaks in solvents with weak hydrogen bonds; ex/em = 570/580 nm, respectively
Quidel Corporation Normal human serum depleted of complement Factor I protein.
Normal human serum depleted of complement Factor I protein.
